Vol 4-4 Original Research Article

Superficial Radiotherapy: Long Term Follow-Up of Highly Selected Basal and Squamous Cell Carcinomas in Skin Cancer Patients

Simon J. Madorsky, MD*, Orr A. Meltzer, BS, Alexander Miller, MD

Skin Cancer and Reconstructive Surgery Center (SCARS Center) at 180 Newport Center Drive, Suite 158, Newport Beach, CA 92660

Superficial radiotherapy (SRT) treatment for non-melanoma skin cancer has been reported to yield variable cure rates. When patients are highly selected, adequate margins of treatment are chosen, and hypofractionation is avoided, cure rates of SRT can approach that of Mohs surgery.

The objective of this study is to evaluate long term results of our center’s SRT selection criteria and define proper decision-making parameters of optimal candidates for treatment, and to review the literature. A retrospective chart analysis was done of all SRT cases from 2012-2018. Location, size, type and depth of the treated tumors were defined. Treatment energy, fractionation, and radiation field size were documented. Recurrences and complications were analyzed. Of 131 treated lesions treated, head and neck lesions (105, 80%) were the most common location, primarily on the lower nose (60, 46%). Of 122 lesions analyzed for recurrence, 2 (1.6%) recurred, with a mean follow-up time of 5 years. Acute ulcerations in 29 (28%) head and neck lesions, 5 (63%) trunk lesions, and 9 (50%) leg lesions occurred. Delayed ulcerations occurred in 5 (28%) leg lesions. In conclusion, when patients are highly selected, long-term SRT cure rates up to 98% can be achieved.

DOI: 10.29245/2767-5092/2022/4.1261 View / Download Pdf
Vol 4-3 Case Report

Successful Use of Brentuximab Vedotin for Treatment of CD30-positive Primary Cutaneous Extranodal Natural Killer/T-Cell Lymphoma

Denise Ann Tsang1*, Chee Leong Cheng2, Laura Hui1

1Singapore General Hospital, Department of Dermatology

2Singapore General Hospital, Department of Pathology

DOI: 10.29245/2767-5092/2022/3.1162 View / Download Pdf
Vol 4-3 Commentary

Commentary: Laser Tattoo Removal: Laser Principles and an Updated Guide for Clinicians

Samantha D. Verling*, Noreen Mohsin#, Loren E Hernandez, Teresa Ju, Keyvan Nouri

Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA

DOI: 10.29245/2767-5092/2022/3.1158 View / Download Pdf
Vol 4-3 Mini Review Article

Effects of Obesity on Infections with Emphasis on Skin Infections and Wound Healing

Daniela Frasca1,2*, Natasa Strbo1,2

1Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL USA

2Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL USA

Obesity represents a serious health problem as it is rapidly increasing worldwide. Obesity is associated with reduced health span and life span, decreased responses to infections and vaccination and increased frequency of inflammatory conditions. In this review, we summarize published data showing that obesity increases the risk of different types of infections, with a special focus on skin infections. Obesity also induces skin changes and conditions (inflammation-based and hypertrophic) which are often associated with fungi or bacteria overgrowth. The association of obesity with the skin microbiome has been established in both mice and humans. Balance of commensal microbes controls skin homeostasis and the host immune response, while changes in normal physiologic skin microbiome composition and pathologic bacteria contribute to skin diseases. We also summarize the major steps in wound healing and how obesity affects each of them. The role that immune cells have in this process is also described. Although the studies summarized in this review clearly demonstrate the deleterious effects of obesity on wound healing, additional studies are needed to better characterize the cellular and molecular mechanisms involved and identify specific targets of intervention.

DOI: 10.29245/2767-5092/2022/3.1157 View / Download Pdf