Commentary: Inhibition of Glutaminase Elicits Senolysis in Therapy-Induced Senescent Melanoma Cells
DOI: 10.29245/2767-5092/2026/3.1217 View / Download PdfElaine Lee1 and Akihiro Yoshida1,2*
1Department of Dermatology, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA.
2Case Comprehensive Cancer Center, Cleveland, OH 44106, USA.
Periocular Molluscum Contagiosum Causing Chronic Unilateral Conjunctivitis and Mimicking Basal Cell Carcinoma
Sveina B. Karlsdóttir*, Nikolaj C. Bjerrum, Flemming Moller
Department of Ophthalmology, Vejle Hospital, University Hospital of Southern Denmark
Molluscum contagiosum is a benign viral skin infection that rarely can cause chronic follicular conjunctivitis when lesions are located near the eyelid margin. It may also mimic other periocular lesions, including basal cell carcinoma.
We present a case of an otherwise healthy 50-year-old man with 18 months of unilateral periocular eczema, irritation, tearing, conjunctival redness, and chronic conjunctivitis. He was referred with clinically suspected periocular basal cell carcinoma. Histopathological examination revealed molluscum contagiosum and after removal of the lesion, the symptoms of chronic conjunctivitis resolved within two months.
Careful inspection of the entire eyelid and eyelid margin is important in chronic unilateral conjunctivitis, even when a single suspicious periocular lesion is identified, as additional subtle molluscum lesions may be present and may contribute to persistent symptoms if left untreated. Removal of the causative lesions can resolve symptoms and prevent unnecessary treatment.
DOI: 10.29245/2767-5092/2026/3.1218 View / Download PdfMulti-Faceted Evaluation of a Facial Cream Across Aging and Targeted GLP-1 Users
Hequn (Tracy) Wang1, Stephen Lynch1*, Frederic Flament2, Elisabeth Bouhadana3, Mallory Hamilton1, Valerie Robert1, Brittany Lee1, Rosangelly Flores1, Paula Cziryak1
1L’Oreal USA Research & Innovation, 30 Terminal Ave, Clark, NJ, 07066, USA
2L’Oreal Research & Innovation, 9 rue Pierre Dreyfus, Clichy, France
3L’OREAL PARIS – Centre Eugene Schueller – Clichy, France
Cutaneous aging results from intrinsic senescence and environmental stressors that degrade collagen, elastin, and hyaluronic acid, leading to wrinkles and loss of skin quality. Topical vitamin C, retinoids, and hyaluronic acid target complementary pathways involved in antioxidant defense, collagen synthesis, epidermal renewal, and hydration. Rapid weight loss from GLP-1–based therapies may further accentuate facial aging, highlighting the need for supportive dermocosmetic strategies. This study aimed to evaluate a dermocosmetic formulation combining ascorbyl glucoside (vitamin Cg), retinyl palmitate (pro-retinol), and hyaluronic acid using a multi-faceted approach integrating instrumental measurements, clinical grading, and finally patient-reported outcomes in conventional aging populations and individuals using GLP-1–based therapies. Dermocosmetic formulation improved skin hydration from 15 min post-application (46%; p<0.001) with an improvement maintained for 24h. Product application over the course of 4 weeks in a general skin aging population had significant improvement on overall skin appearance and on all skin aging parameters evaluated, with several parameters showing significance from week 1. Particularly, skin roughness significantly decreased (-44%; p<0.001), while skin firmness and radiance increased by 21% and 20%, respectively (p<0.001). These improvements were accompanied by a significant reduction of -29% and -26% (p<0.001) in global fine lines and wrinkles by week 4. Moreover, dermocosmetic formulation potentially responds to GLP-1 users' skin concerns according to self-reported benefits. GLP-1 users, specifically for weight loss, were highly satisfied with product performance after 4 weeks of use (86%), likewise a majority of GLP-1 users agreed that the product was a “great ally/companion” for their skin during their weight loss period.
DOI: 10.29245/2767-5092/2026/2.1214 View / Download Pdf