Vol 4-3 Commentary

Commentary: Laser Tattoo Removal: Laser Principles and an Updated Guide for Clinicians

Samantha D. Verling*, Noreen Mohsin#, Loren E Hernandez, Teresa Ju, Keyvan Nouri

Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA

DOI: 10.29245/2767-5092/2022/3.1158 View / Download Pdf
Vol 4-3 Mini Review Article

Effects of Obesity on Infections with Emphasis on Skin Infections and Wound Healing

Daniela Frasca1,2*, Natasa Strbo1,2

1Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL USA

2Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL USA

Obesity represents a serious health problem as it is rapidly increasing worldwide. Obesity is associated with reduced health span and life span, decreased responses to infections and vaccination and increased frequency of inflammatory conditions. In this review, we summarize published data showing that obesity increases the risk of different types of infections, with a special focus on skin infections. Obesity also induces skin changes and conditions (inflammation-based and hypertrophic) which are often associated with fungi or bacteria overgrowth. The association of obesity with the skin microbiome has been established in both mice and humans. Balance of commensal microbes controls skin homeostasis and the host immune response, while changes in normal physiologic skin microbiome composition and pathologic bacteria contribute to skin diseases. We also summarize the major steps in wound healing and how obesity affects each of them. The role that immune cells have in this process is also described. Although the studies summarized in this review clearly demonstrate the deleterious effects of obesity on wound healing, additional studies are needed to better characterize the cellular and molecular mechanisms involved and identify specific targets of intervention.

DOI: 10.29245/2767-5092/2022/3.1157 View / Download Pdf