Vol 6-2 Case Report

Successful Remission of Necrobiosis Lipoidica Manifested by Subcutaneous Nodules with Tofacitinib: A Case Report

Wei Zhang, Huiqian Yu, Shuping Wu, Yuhui Shi, Siyuan Chang, Yan Li*

Department of Dermatology, Henan Provincial People′s Hospital, Zhengzhou University People′s Hospital, Henan University People′s Hospital, Zhengzhou 450003, China

DOI: 10.29245/2767-5092/2024/2.1188 View / Download Pdf
Vol 6-2 Original Research Article

Method For Preparing a Skin Repairing Ingredient from Cheese Whey Following Lactobacillus Fermentation

Tania Flutto*, Laura Thedy, Simona Zenato, Rita Pramotton, Luca Vernetti-Prot, Sabina Valentini

Institut Agricole Régional, 11100 Aosta, Italy

In case of impairments in skin integrity, the use of dermatological treatments may prevent the outbreaks of diseases, by restoring the physiological homeostasis of the injured tissue. Against this background, a method for preparing an active ingredient effective on wound healing has been developed, starting from sweet whey, a by-product of Fontina PDO cheese processing. Following the fractionation of whey constituents by ultrafiltration processes, the obtained permeate underwent controlled fermentation by a newly characterized Lactobacillus delbrueckii MF-20/7A/24 (BCCM accession number LMG P-31789) isolated in alpine pasture of Aosta Valley, a little region in the Northwest of Italy. The ability of the native bacterial strain was exploited to ferment the whey permeate fraction, in order to enhance its potentially bioactive components. In particular, the whey-based fermented product was rich in biomolecules with a potentially beneficial effect on human skin, including galacto-oligosaccharides and organic acids. The prepared ingredient, subject of a specific Italian patent (N. 102021000011006), showed the ability in vitro to induce skin wound healing, due to the presence of galacto-oligosaccharides (GOS) and butyric acid. As evidenced by the tests carried out, no cytotoxic reactivity or interferences with cell growth and cytoplasmatic metabolism were found out. Moreover, data from patch test on adult volunteers with sensitive skin confirmed the absence of irritating properties of the preparation.

DOI: 10.29245/2767-5092/2024/2.1183 View / Download Pdf
Vol 6-2 Commentary

Diethyl Azelate for the Treatment of Brown Recluse Spider Bite, a Neglected Orphan Indication: A Commentary

Elzbieta Izbicka*, Robert T. Streeper

New Frontier Labs LLC, San Antonio, Texas, U.S.A

Both the authors contributed equally to this work

DOI: 10.29245/2767-5092/2024/2.1181 View / Download Pdf
Vol 6-2 Editorial

Self-Supervised Learning in Skin Cancer Detection: The Roles of Topological Contrastive Learning with Geometric Analysis

Yashbir Singh1, Quincy A. Hathaway2, Bradley J. Erickson3

1Radiology, Mayo Clinic, Rochester, MN, USA

2Department of Medical Education, West Virginia University, Morgantown, West Virginia, USA

3Radiology, Mayo Clinic, Rochester, MN, USA

DOI: 10.29245/2767-5092/2024/2.1182 View / Download Pdf