Commentary: DNA Damage Promotes Epithelial Hyperplasia and Fate Mis-specification via Fibroblast Inflammasome Activation
DOI: 10.29245/2767-5092/2022/2.1154 View / Download PdfDavid Solano1, Kush R. Patel1#, Adelaida B. Perez1#, Lindsey Seldin1-4*
1Department of Cell Biology, Emory University School of Medicine, Atlanta, GA, USA
2Department of Dermatology, Emory University School of Medicine, Atlanta, GA, USA
3Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA
4Atlanta Veterans Affairs Medical Center, Decatur, GA, USA
#Authors contributed equally
Antimicrobial Photodynamic Therapy of Human Skin
Alison M Mackay
Division of Musculoskeletal and Dermatological sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
Photodynamic therapy (aPDT) has become an important component in the treatment of human infection. This report highlights the scientific literature and clinical guidelines on aPDT in the context of dermatology and considers the treatment of skin infection in all settings now, and in the future. Antibiotic resistance, infection control strategies and technologies able to eradicate microbes without building up new resistance are considered, and their mechanisms of action are described. Published work and National Institute for Clinical Excellence (NICE) Technology appraisals (TA) and research recommendations within Clinical Guidelines were used to identify future applications for PDT. Nanotheranostics can include PDT and were found to be highly relevant, and so treatment combinations and their novel applications will be subject to TA and Randomised Clinical Trials (RCTs). The resistance of some microbes to antibiotics can be reversed through use of supplementary drugs, and so they are likely to remain a mainstay of treatment for skin infection.
DOI: 10.29245/2767-5092/2022/2.1153 View / Download PdfCommentary: Sport-specific Factors Impacting Solar Ultraviolet Exposure in Individuals Who Perform Outdoor Sport Activities
DOI: 10.29245/2767-5092/2022/2.1151 View / Download PdfLaura Andrews, BS1*; Chelsea Shope, BA1; Alan Snyder, MD MSCR2, Manuel Valdebran MD3
1College of Medicine, Medical University of South Carolina
2Department of Dermatology & Dermatologic Surgery, Medical University of South Carolina
3Department of Dermatology & Dermatologic Surgery, Division of Pediatric Dermatology Medical University of South Carolina
Silica and Connective Tissue Disorders: The Important Role of the Dermatologist
Deborah H Yates1,2,3*, Susan E Miles4,5
1Department of Respiratory Medicine, St Vincent’s Public Hospital
2St Vincents Clinical School, UNSW
3Holdsworth House Medical Practice, Sydney, NSW
4Department of General Medicine at Calvary Mater Newcastle
5University of Newcastle, Newcastle, NSW, Australia 2308
Dermatological manifestations of connective tissue diseases (CTDs) are common and frequently precede other symptoms. Thus, dermatologists may be the first clinicians to diagnose these disorders. Silica exposure is an acknowledged cause of several CTDs, but this is under-appreciated by clinicians, who may also be unaware of the wide range of jobs in which silica exposure can occur. The CTDs associated with silica exposure include systemic sclerosis (SSc), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), anti-neutrophil cytoplasmic antibody (ANCA) positive vasculitis and overlap syndromes. Silica-related systemic sclerosis (Si-SSc) is associated with a specific antibody profile and more severe disease. Silicosis has re-emerged worldwide recently due to several new workplace exposures, including a new type of silicosis (artificial stone (AS) silicosis), which is associated with a particularly high rate of auto-antibody formation. Dangerous work practices are still occurring. This article summarises recent literature on the topic of the resurgence of silicosis and silica-induced CTDs and reminds dermatologists of the importance of taking a thorough occupational history in all patients. Early intervention in CTDs and reduction in dust exposure can reduce risk and improve prognosis. Treatment options are rapidly improving.
DOI: 10.29245/2767-5092/2022/2.1147 View / Download PdfCommentary: Solar Ultraviolet Exposure in Individuals Who Perform Outdoor Sport Activities
DOI: 10.29245/2767-5092/2022/2.1150 View / Download PdfChelsea Shope, BA1*, Laura Andrews, BS1, Alan Snyder, MD MSCR2, Manuel Valdebran MD3
1College of Medicine, Medical University of South Carolina
2Department of Dermatology & Dermatologic Surgery, Medical University of South Carolina
3Department of Dermatology & Dermatologic Surgery, Division of Pediatric Dermatology Medical University of South Carolina