Multi-Faceted Evaluation of a Facial Cream Across Aging and Targeted GLP-1 Users
Cutaneous aging results from intrinsic senescence and environmental stressors that degrade collagen, elastin, and hyaluronic acid, leading to wrinkles and loss of skin quality. Topical vitamin C, retinoids, and hyaluronic acid target complementary pathways involved in antioxidant defense, collagen synthesis, epidermal renewal, and hydration. Rapid weight loss from GLP-1–based therapies may further accentuate facial aging, highlighting the need for supportive dermocosmetic strategies. This study aimed to evaluate a dermocosmetic formulation combining ascorbyl glucoside (vitamin Cg), retinyl palmitate (pro-retinol), and hyaluronic acid using a multi-faceted approach integrating instrumental measurements, clinical grading, and finally patient-reported outcomes in conventional aging populations and individuals using GLP-1–based therapies. Dermocosmetic formulation improved skin hydration from 15 min post-application (46%; p<0.001) with an improvement maintained for 24h. Product application over the course of 4 weeks in a general skin aging population had significant improvement on overall skin appearance and on all skin aging parameters evaluated, with several parameters showing significance from week 1. Particularly, skin roughness significantly decreased (-44%; p<0.001), while skin firmness and radiance increased by 21% and 20%, respectively (p<0.001). These improvements were accompanied by a significant reduction of -29% and -26% (p<0.001) in global fine lines and wrinkles by week 4. Moreover, dermocosmetic formulation potentially responds to GLP-1 users' skin concerns according to self-reported benefits. GLP-1 users, specifically for weight loss, were highly satisfied with product performance after 4 weeks of use (86%), likewise a majority of GLP-1 users agreed that the product was a “great ally/companion” for their skin during their weight loss period.
DOI: 10.29245/2767-5092/2026/2.1214 View / Download Pdf