Commentary: A Stepwise Approach to the Treatment of Lichen Planopilaris
View / Download PdfJohn Plante*, Chelsea Eason, Alan Snyder, Dirk Elston
Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, South Carolina
Commentary: Soft Tissue Coverage for Severe Infections
View / Download PdfAdam Strohl
Philadelphia Hand to Shoulder Center, Thomas Jefferson University Hospital, Philadelphia, PA
Commentary on “Leukocyte-Cancer Cell Fusion-Genesis of a Deadly Journey”
View / Download PdfJohn M. Pawelek
Department of Dermatology and the Yale Comprehensive Cancer Center, New Haven, CT
Keeping a Secretome: Emerging Roles for Epithelial Integrins in Controlling a Stroma-Supportive Secretome
View / Download PdfWhitney M. Longmate*
Department of Surgery, Albany Medical College, Albany, NY 12208, USA
Burn-derived Mesenchymal Stem Cells in Wound Healing
Roohi Vinaik1, Marc G. Jeschke1,2,3,4*
1Sunnybrook Research Institute, Toronto, Canada
2Department of Surgery, Division of Plastic Surgery, University of Toronto, Canada
3Department of Immunology, University of Toronto, Canada
4Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre, Toronto, Canada
Thermal injury is a severe form of trauma that is accompanied by significant, persistent metabolic and immune dysregulation. The extent of altered post-burn metabolism and inflammation is correlated with severity of injury, with severe burns demonstrating a more significant hypermetabolic, hyperinflammatory response. This in turn delays re-epithelialization and exacerbates poor post-burn wound healing, which is the most important factor in patient mortality outcomes. Recently, stem cells have gained interest in burn wound healing applications due to their capacity to produce multiple cellular subtypes and improve the rate and quality of healing. Here, we focus on applications of mesenchymal stem cells in wound healing. In particular, we highlight the characteristics and efficacy of burn-derived mesenchymal stem cells (BD-MSCs), which improve healing in animal models. Discarded burn tissue is a source of pro-healing BD-MSCs, providing a safe, non-invasive therapeutic option for burn patients.
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