Vol 2-2 Commentary

Commentary: A Stepwise Approach to the Treatment of Lichen Planopilaris

John Plante*, Chelsea Eason, Alan Snyder, Dirk Elston

Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, South Carolina

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Vol 2-2 Commentary

Commentary: Soft Tissue Coverage for Severe Infections

Adam Strohl

Philadelphia Hand to Shoulder Center, Thomas Jefferson University Hospital, Philadelphia, PA

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Vol 2-2 Commentary

Commentary on “Leukocyte-Cancer Cell Fusion-Genesis of a Deadly Journey”

John M. Pawelek

Department of Dermatology and the Yale Comprehensive Cancer Center, New Haven, CT

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Vol 2-2 Mini Review Article

Keeping a Secretome: Emerging Roles for Epithelial Integrins in Controlling a Stroma-Supportive Secretome

Whitney M. Longmate*

Department of Surgery, Albany Medical College, Albany, NY 12208, USA

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Vol 2-2 Mini Review Article

Burn-derived Mesenchymal Stem Cells in Wound Healing

Roohi Vinaik1, Marc G. Jeschke1,2,3,4*

1Sunnybrook Research Institute, Toronto, Canada

2Department of Surgery, Division of Plastic Surgery, University of Toronto, Canada

3Department of Immunology, University of Toronto, Canada

4Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre, Toronto, Canada

Thermal injury is a severe form of trauma that is accompanied by significant, persistent metabolic and immune dysregulation. The extent of altered post-burn metabolism and inflammation is correlated with severity of injury, with severe burns demonstrating a more significant hypermetabolic, hyperinflammatory response. This in turn delays re-epithelialization and exacerbates poor post-burn wound healing, which is the most important factor in patient mortality outcomes. Recently, stem cells have gained interest in burn wound healing applications due to their capacity to produce multiple cellular subtypes and improve the rate and quality of healing. Here, we focus on applications of mesenchymal stem cells in wound healing. In particular, we highlight the characteristics and efficacy of burn-derived mesenchymal stem cells (BD-MSCs), which improve healing in animal models. Discarded burn tissue is a source of pro-healing BD-MSCs, providing a safe, non-invasive therapeutic option for burn patients.

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